.Product Description
New Nucleofill Pn2.5% Facial Skin Moisturizer Sodium Profhilo H+L Dermal Filler Rejuvenation Facial Lift
NucleoFILL is a preparation for deep renewal and biostimulation of the skin, developed on the basis of natural polynucleotides.
Biostimulation of the skin consists in stimulating its own regenerative capabilities - skin renewal occurs thanks to the occurrence of natural processes. In the case of products that are biostimulants, the effect intensifies over time and the therapy requires a series of treatments.
Polynucleotides are small fragments of DNA and RNA nucleic acids, found in all organisms. They are entirely biocompatabilable with the human body. Polynucleotides have the ability to spatially attach a large number of water molecules, increasing tissue hydration, they also affect the increase in the number and activity of fibroblasts, i.e. the most important cells responsible for the continuous restoration of many skin components. In addition, they also play an important role in combating free radicals and inhibit photoaging, effectively protecting the skin against sun exposure. NucleoFILL is an innovative treatment that, using the beneficial properties of polynucleotides, works on three levels, stimulating the skin to rebuild.
hree mechanisms of action
- lifting - stimulating the process of collagen type I and elastin production, which causes thickening of the skin and its lifting,
- antioxidant effect and elimination of free radicals that arise as a result of many different factors such as strong, long-term stress, smoking, breathing polluted air, high physical exertion, intense sunbathing, inadequate diet,
- moisturizing - binding water by polynucleotides and ensuring long-term hydration of the matrix extracellular, thanks to which the skin becomes moisturized, firm and elastic.
Who is the treatment for?
Due to the variety of treatment protocols, NucleoFILL treatment can be performed in all patients - regardless of age and skin type. It can be used as a prophylaxis and as a "repair" and anti-aging treatment.
Below you can find details of four different NucleoFILL variants and their treatment indications.
NucleoFILL Medium NucleoFILL Strong NucleoFILL PLUS Hair NucleoFILL Soft Eyes Procedure Number and frequency of treatments Effects Contraindications Price list
The synergy of 4 types of stimulation:
Skin regeneration
Cleansing effect on the cells by increasing circulation and removing free radicals
Deep moisturizing effect
Firming and contouring
Nucleofill is the new line of natural polynucleotide-based bio-stimulating gels, with a high viscosity, for protecting and rejuvenating the skin.
The unique features of NucleoFILL
The product contains high molecular weight polynucleotide chains whose biochemical peculiarities make it highly viscoelastic and capable of binding and orient in space a considerable amount of water molecules, which are primarily retained in the hydrophilic groups level of phosphorylated sugars of the individual nucleotides.
Moisturizing effect
The strong moisturizing ability is mainly due to the water retention capabilities of the hydrophilic groups of the phosphorylated sugars of the single nucleotides.
An "electrostatic sponge" is able to guarantee cellular well-being by conferring deep hydration to tissues.
Free radical scavenger effect
The polymeric macromolecules are able to also play an immediate "scavenger" action against free radicals.
This effect of this polynucleotide gel is possible thanks to the chemical structure capable of blocking free radicals in the nitrogenous ring.
Moreover, the progressive degradation of polynucleotide molecules by enzymes present in the extracellular environment, free metabolites which, in turn, accentuate the protection activity against free radicals.
Biostimulating effect
The bio-stimulating effect is given both by the presence of nucleoside structures capable of activating cell membrane receptors and by metabolites that are produced by the enzymatic attack during the degradation process. A slow and continuous effect.
By promoting the metabolic activity of the fibroblastic cells, polynucleotides collaborate to reintegrate into the dermis various fundamental autologous components (glucoseaminoglycans, proteins, glycoproteins, fibrils, etc.) tending to maintain their physiological functionality.
Their repeated administration over time determines:
- protracted isosmotic hydration of the dermal matrix
- an anti-radical action
Both of these effects combine to recreate in the dermal matrix the most favorable physiological conditions for the regeneration and metabolic activity of fibroblasts, with long-lasting biorevitalizing effects.
The maturation of fibroblasts in myofibroblasts and the production of collagen determines a strong specific lifting and revitalizing effect suitable for all skin types.
Indications:
Skin laxity with poor circulation
Dehydrated skin
Skin submitted to oxidative stress
Stretch marks
Scars
For those who want firming and contouring, more definition.
Bio-stimulation and increase in collagen type 1.
It's recommended to have 2 treatments with 2-4 weeks in between each session, in severe cases you can have up to 4 treatments with 2-4 weeks intervals.
Side effects:
Bruising may occur
Some swelling in the injection area 1-2 days
No other side effects have been reported.
Benefits:
Nucleofill: a specific mechanism of action for optimal bio revitalization.
Polynucleotides activate two types of membrane receptors in fibroblasts:
- Receptor CD39
- Receptor CD40
The activation of these receptors leads to two effects:
- Stimulation of type I collagen production
- Maturation of fibroblasts in myofibroblasts
Audited Supplier 
){kind=link}